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Published by Elsevier Ltd. All rights reserved. 1742-7061 10.1016/j.actbio.2019.09.001 https://doi.org/10.1016/j.actbio.2019.09.001 P 10.1016/j.actbio.2019.09.001 noindex Elsevier 2019-09-14T13:08:42+05:30 2019-09-14T13:07:36+05:30 2019-09-14T13:08:42+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:1d07cb97-65c8-4328-9193-f5f71bac2f1d uuid:d3271a09-51a7-4020-8a69-6416015050ca endstream endobj 343 0 obj <>stream HlAO &~M,ni,[L<+l6R@-m~#hWՕp tTv9d 0` 6@DŽ4EdHSr$8+Ȝ.R<LqcU?)mۢv9b\.{JDoX){30FVXnڕZ^n\ao_^7Fc!E% |Sh u;V{wF7F0͛fl3}vwAVpDŽ10*,W)UcC ?×+tO*:氋 q`tpŸۗ[v e'&È`t endstream endobj 344 0 obj <>stream Hko>߯1jW,un˶ɹ'!\»;FHӯ:vf3VSs~y|lqթ()&Kr҃;A7ài% N:lٷ1N hwp`d@Oau:ϹMtNx] ^AYfzȧ4> A_ܒҪIe< [yatuH/K:x~g)[-KnH;-_G3Tj%\GDḘ2z' KߛDžlܤ@U|uʏǞxi[i+ˢжYZr}pXYEgF}0plB&{:wm9Hg474zoGaAm^HQN<=v ./ͭp"0H8Lh8͌@ =6ȻқJ+//^!.2oBHV gypȭȬMϔs]tKyFUe>Fkя¦N'Q׳.Qm! 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ҢmS7kTX\oKi'v eA 9S>?'TyS픫I#zdr0LFR9"(Cj͈0MTԌ) Bszz vtԥ(OBk1Cy&RfLOutOn[\ 沑+PA#)]6U֕;h?-Nc+EJ%wHqH?㙜Ѫ-[,fux<\JHQ}\ҪҠIi]oqJHkAKӯmtd>v_vLTv7HA!|u;T]].}}ĂYN]^ zJ=?k"!лx3 TuYAt>>z+t{>ɼ}sd@_|E;36pNHK[r0\wZNb[yS^u֚o=+/H* fsGGpV{]L~j](\4! dM2N.g|%%лA͖hZ؏I֬ IeΏf1WDòfמ!DXQ8{k^}3`w6p|YsI0>29u7W.t;yZk˩v^q =ksn&I^#YRÂ˓"l`֐U:ƇMۉZpUԆsƶEIhn5SAAr:ce y 59I*\ZY"-HPvŌ!LF^DVѺ)bWw>[8HG2; L x]Ud>d Gy,U|VikjƓwg'7qS)|Q"ek/n>P#v x. 6 S+$ (գ;SǣNg( diKJ+ꅝ2Htײ0nĐaBWfq@΃#ԆcB2ȿSysZ0 Yi-`1 !0bîjeU9  _+} %QJ)k=*W;=btX;,-tx=6WS4^L#p@8#yap<aL =nsJAk[آ<g}|b!>8Ii$dDBA+6EsZR8F&"y<~"Wq;L9'0\P2M~t糅 RVDJbn}Xk8IPk@_ x"2yyV#ȳwӟӟ1g9brĜs3;cN7brĜs3'u3gi_jDuV:K gKl=)Q$%JWE$Zy2Yi3iO@0P#QI 1 YbV YJhUp\Wu3Q+ -\q>`uǼfCTg$ P* j17Rz"G^D=K1*V-SG1r&YE "aB'^ >L}`g~eB8YJZ"c#V٠jj2k‡MD"ewÊg=@Ea< vrQZ|1>c|VQ~p!bG8E:p~@@a%RR]N/LSB nKɫEϒ_9BjXɏufwL9v闫'f߯ڵ,9Ŝ?,׺$w?GWǯuo&Vsu>iud^ܽ-nRBUl_bc}sqM0;v~z6k5f-ͦٯJs8o^xn}hv5nn p[~}&-op+n鶽fw# gy%A[|͡ozϹO#r=-6۶ӂ%㭼4𐳌h|\meoV[vIammO:S4kPw[FMz3@~LFH~X9$D52sX!3D7 @i0es`NFIIhcb+}L=Ph|c`hN \u% ,\ a5)orO endstream endobj 3 0 obj <>stream H\Pj s=,UۅC>I*4*Ͳ8|?|tλ =cyp k2NγLO6ߖsA'<2,&'8|]#~g(G2zUN%D?:7{,.QLOȤR oTF3q8 EۮҊP+.w~o#YSu75`<>CR~Rt endstream endobj 4 0 obj <>stream application/pdf doi:10.1016/j.actbio.2019.09.001 A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition Tao Zhang Hui Liu Yating Li Chunyu Li Guoyun Wan Bowei Chen Chunxia Li Yinsong Wang Marine sulfated polysaccharide pH-sensitive nanoparticles Doxorubicin Celecoxib Metastatic breast cancer Acta Biomaterialia, Corrected proof. doi:10.1016/j.actbio.2019.09.001 Acta Materialia Inc. journal Acta Biomaterialia © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. 1742-7061 10.1016/j.actbio.2019.09.001 https://doi.org/10.1016/j.actbio.2019.09.001 P 10.1016/j.actbio.2019.09.001 noindex 6.5 Elsevier 2019-09-14T13:08:42+05:30 2019-09-14T13:07:36+05:30 2019-09-14T13:08:42+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:1d07cb97-65c8-4328-9193-f5f71bac2f1d uuid:d3271a09-51a7-4020-8a69-6416015050ca endstream endobj 5 0 obj <>stream HlRMo / %+jHZ[S=fEmߏ~sf >///qM*e.4N ՖSߔ1-8k6̕ D#/ Q8"w+Ș @ uOs(k+|FRzd2i\s |IjO֣3Yp颲lN6!>Eg ^ri &?蠐72UUlGs͙Uz7!N|>2B~w`:AWzXvXg&Q D^b|m ~2* & IX82]mB\!^67۽J;nہo͡o endstream endobj 6 0 obj <>stream HWYL}7b^EqbwAhS}o/w!<$Yդ a 0TO]hE'{ocN /O]8:{e}'E=E8Ab8p2&$ݹ_ݿcj'/ޣ!y<,C:0LB}guêf_ZogfŹƆȟй[WHV21۷;3x wWF=x0`'4 3 Ow"fh1Oa_F9JƱY[,7p (գʩY6;fk~8 Otb4 >W";׿G[Ă9]L,Oݢɀ р% $GS#X%O,i#IF?YcgO]Sf[/N0bڡY?uEgƩ毰vcv"^7S͛{MoL|v}wBه0Gx >b=6KEp g?չIYpDu?\s\*ڲ }rzSc!ri`# `̐ܫ%1/Pb) C/Ao.KԆ.Xox93HpN`*XY"aƕ:΂ќ+y+ȳ@A*kW<"BU*3j|z̖E8HZZw?1JTuPRS RlA*o*r*ϙqebN95Z 7Q9 U Z,ECڴR$gC%vVeWޘj*ꋦ_y}jt-(<^LHqstgtM!ZAbNᎨ쎤 N0+>2;V{7 ް^>G=2l>V093Gx bʋRH]# ?Yz8fQ A4;usV0:ɥp3ˌxDžyzfiK)ϞYK4dRN ;\rE7Fkͷm|ڋ'4XI"[v;0#u$K ã$ŞZ_M> $,AOL_sv3^mo&i+y^|h["^3yjo4/VY |5Nj0o R  v:h2)HSk IU3umUʓM8::uzdzpx)BMh4k1t 賱_wg} )anR/½&NCh䞺mܔ:T39_>stream application/pdf doi:10.1016/j.actbio.2019.09.001 A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition Tao Zhang Hui Liu Yating Li Chunyu Li Guoyun Wan Bowei Chen Chunxia Li Yinsong Wang Marine sulfated polysaccharide pH-sensitive nanoparticles Doxorubicin Celecoxib Metastatic breast cancer Acta Biomaterialia, Corrected proof. doi:10.1016/j.actbio.2019.09.001 Acta Materialia Inc. journal Acta Biomaterialia © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. 1742-7061 10.1016/j.actbio.2019.09.001 https://doi.org/10.1016/j.actbio.2019.09.001 P 10.1016/j.actbio.2019.09.001 noindex 6.5 Elsevier 2019-09-14T13:08:42+05:30 2019-09-14T13:07:36+05:30 2019-09-14T13:08:42+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:1d07cb97-65c8-4328-9193-f5f71bac2f1d uuid:d3271a09-51a7-4020-8a69-6416015050ca endstream endobj 8 0 obj <>stream HlRMo / %+jHZ[S=fEmߏ~sf >///qM*e.4N ՖSߔ1-8k6̕ D#/ Q8"w+Ș @ uOs(k+|FRzd2i\s |IjO֣3Yp颲lN6!>Eg ^ri &?蠐72UUlGs͙Uz7!N|>2B~w`:AWzXvXg&Q D^b|m ~2* & IX82]mB\!^67۽J;nہo͡o endstream endobj 9 0 obj <>stream HWYL}7b^EqbwAhS}o/w!<$Yդ a 0TO]hE'{ocN /O]8:{e}'E=E8Ab8p2&$ݹ_ݿcj'/ޣ!y<,C:0LB}guêf_ZogfŹƆȟй[WHV21۷;3x wWF=x0`'4 3 Ow"fh1Oa_F9JƱY[,7p (գʩY6;fk~8 Otb4 >W";׿G[Ă9]L,Oݢɀ р% $GS#X%O,i#IF?YcgO]Sf[/N0bڡY?uEgƩ毰vcv"^7S͛{MoL|v}wBه0Gx >b=6KEp g?չIYpDu?\s\*ڲ }rzSc!ri`# `̐ܫ%1/Pb) C/Ao.KԆ.Xox93HpN`*XY"aƕ:΂ќ+y+ȳ@A*kW<"BU*3j|z̖E8HZZw?1JTuPRS RlA*o*r*ϙqebN95Z 7Q9 U Z,ECڴR$gC%vVeWޘj*ꋦ_y}jt-(<^LHqstgtM!ZAbNᎨ쎤 N0+>2;V{7 ް^>G=2l>V093Gx bʋRH]# ?Yz8fQ A4;usV0:ɥp3ˌxDžyzfiK)ϞYK4dRN ;\rE7Fkͷm|ڋ'4XI"[v;0#u$K ã$ŞZ_M> $,AOL_sv3^mo&i+y^|h["^3yjo4/VY |5Nj0o R  v:h2)HSk IU3umUʓM8::uzdzpx)BMh4k1t 賱_wg} )anR/½&NCh䞺mܔ:T39_>stream h242R0P042V07R& 1)Z @BDF)85/9?%3/]?<318wLKK-JKN-66ЯJ-w6,HՇZX`tD)HH?4-&،昖Yߒb٥h) endstream endobj 11 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/StructParents 2/TrimBox[0.0 0.0 595.276 793.701]/Type/Page>> endobj 12 0 obj <>stream HWnH}W𱵈h$$wdD-Q2wDR!){:դĚ Cp/u9ufU˗Oߞ.x48:E(XG(dqdØWߨ0 Bg#L#1G瓣$뒽 ]>0Jut UEvN_.QGu=S=_ PEH/퍲Ư fs/ZLQi5$$ܳDDT?1F?wm\Mo3%2zE@+QM77rHR( ek$.RHX.P9kK_ļhzuGc&E5ȆR0IMy(w44ʪySoZi0겢*%f= *d^࿦ h,ƣN~!PGi09#&렒NݬۅVd Up[p7b1JE} h/#onƧp|~ "d`d|dY&haˊu BHYdt)I=ݝgɫ|IZ>7m*ʾ[f3T IR`6՜2l5ω.rOXq#p5N٪WA+ 7 >iRDcC0 !I˥჋FGjsWmMYX]^3(Pʰ*.`R)-T*/%[8;ސ)%Y[W+& q*A9eH*ȈfL N) BO)E%k"|z#x>H閊x9hjJԆydLy}z-d1cQ]ծY^#̧]>h!ef ˭ ,KH7eL5Y3 e6-CeJQ8fu% PeBKas"n%5$ƒWxHן^_-x-Fj~[;̀\*_~{uM4?/Zɛ2V%#dGZ+b*7-YVU38+bj# PSqu }JtEIEaWŌD7 h$ד'b aivV#g7[ =cZE[;Yjhbu^;ӄtܯy$- }{G/2`X;͊x_wSb8܉-nWMOMK$gY9@ٖeƈ(7wEͿm^JQCDJ`ةpDa$M0i"4Pn51pC뎝i۰/%FpX&Ľ Hi*)UHr9.7>}5g>o%^&Ywy񘻮&B!6}#+bR ^tP'N?xM($y-=XȔ8NF;L\GOw 91~w O/hK_ C{oZ%{7֊:.hb;**+ Ϣ;zrtlIJ.U@$0H'$(V?!׍ߝ"y$A"'O;8ퟡ=;#Čs?^X}rMIfz A(Pj)LjNֶA0!p vhwxcxLK]Q#xơ8}h{v6 Qx8t}U ~Q^@BKCט8IJ!Ȏ .Kq 0dP-Na+wp"!@ bC^F:`G oUhZo?`vd.$a.Tf_.pGwkFiopYhۗѬL1H^VE octC-te 4 YǦh%=fy۲Н-ZUU`v!Uq~)3![f(co1kys/%آK~s%I+C& dˇR@X^t F0^@a)oz5/aeWf~ݲj F͛KMaf:r3f nw ȑ<2c~LU TWlYɪ?nq~DFN;)$IcXaMFQ[җTiMZ}/XsG$3԰MpdJ1Fᠻ-?bK)G% 'dMnݭx%.+:ĎlB8lv1U&D@ab]fJP"x@b) [R+v} /x&1*^M\i'hW1B:Df ͖yYJhv+~uxT0?t_ f燗 u9'*~1; Q."}[$_ !`w5I[Zb*6svwo/Dp؃EU#Y!#[ؐo^q5I&1t{gPc7+0/fV'Ɠ?M[- ѣyZǴRTMqmWu"U93dAv ^`oxJ`[ 2N C{-6h-C'6w{hJ$4!ê@rtT݈RR fչf~pXuG?kcv IiJ}T޼%r7r<v7-.[B3 HTV ]iƍMT @IW9HA:܋y=ՑC3sflBPjݼB!/^ُhtQklY⇽gĢ%G|/?֍*Z9Mc`##Ca?7 6Vt.?, ǢYwtkWA?@x3%P[pr~*7r#Q=jGͶHEXVq^n̤AF. dfry[6DM7!<EUU=gӂ[%z68}羶, bwD8-XUUE'\YcHc/Zb4oY7A B~t/_p)Sg}]hN7?|ho7oV5%U#Yt{bL iG&Q@_R*^16:7og*^V%eؖG;S%‚Эᜄf>ꃎqs[%V +@QQ8o10x#/R*-$|0֨$jd03 ohv*K8]c@~b+5>Ɠ`w'gR{t)b8TrS1(u 1 ҵ8k7^Ci R`qcz5RvN'Wd5ʘ<n'ήa19 `E@VfY00 -_X4L!](R*.ᝨ*ϱü9pJri0[-[ PZ@<$vT֘aN,?z> pMS/ P5GOv61 adu?`ߦDoںc^3*K2Q`"T* 7ҁ A^pN1"UJ|sQVQBp|'B70Wȥ2&1ir+.fi=aWv,fd1vA)t U˜"xD/,Oßć#~谿):$:ItItIx9h˛츙ţ:ҳ"r!vNIU༴Sl8#ɧ]ѩ\3[[:m͟˜# endstream endobj 13 0 obj <>stream application/pdf doi:10.1016/j.actbio.2019.09.001 A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition Tao Zhang Hui Liu Yating Li Chunyu Li Guoyun Wan Bowei Chen Chunxia Li Yinsong Wang Marine sulfated polysaccharide pH-sensitive nanoparticles Doxorubicin Celecoxib Metastatic breast cancer Acta Biomaterialia, Corrected proof. doi:10.1016/j.actbio.2019.09.001 Acta Materialia Inc. journal Acta Biomaterialia © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. 1742-7061 10.1016/j.actbio.2019.09.001 https://doi.org/10.1016/j.actbio.2019.09.001 P 10.1016/j.actbio.2019.09.001 noindex 6.5 Elsevier 2019-09-14T13:08:42+05:30 2019-09-14T13:07:36+05:30 2019-09-14T13:08:42+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:1d07cb97-65c8-4328-9193-f5f71bac2f1d uuid:d3271a09-51a7-4020-8a69-6416015050ca endstream endobj 14 0 obj <>stream HlRMo / %+jHZ[S=fEmߏ~sf >///qM*e.4N ՖSߔ1-8k6̕ D#/ Q8"w+Ș @ uOs(k+|FRzd2i\s |IjO֣3Yp颲lN6!>Eg ^ri &?蠐72UUlGs͙Uz7!N|>2B~w`:AWzXvXg&Q D^b|m ~2* & IX82]mB\!^67۽J;nہo͡o endstream endobj 15 0 obj <>stream HWYL}7b^EqbwAhS}o/w!<$Yդ a 0TO]hE'{ocN /O]8:{e}'E=E8Ab8p2&$ݹ_ݿcj'/ޣ!y<,C:0LB}guêf_ZogfŹƆȟй[WHV21۷;3x wWF=x0`'4 3 Ow"fh1Oa_F9JƱY[,7p (գʩY6;fk~8 Otb4 >W";׿G[Ă9]L,Oݢɀ р% $GS#X%O,i#IF?YcgO]Sf[/N0bڡY?uEgƩ毰vcv"^7S͛{MoL|v}wBه0Gx >b=6KEp g?չIYpDu?\s\*ڲ }rzSc!ri`# `̐ܫ%1/Pb) C/Ao.KԆ.Xox93HpN`*XY"aƕ:΂ќ+y+ȳ@A*kW<"BU*3j|z̖E8HZZw?1JTuPRS RlA*o*r*ϙqebN95Z 7Q9 U Z,ECڴR$gC%vVeWޘj*ꋦ_y}jt-(<^LHqstgtM!ZAbNᎨ쎤 N0+>2;V{7 ް^>G=2l>V093Gx bʋRH]# ?Yz8fQ A4;usV0:ɥp3ˌxDžyzfiK)ϞYK4dRN ;\rE7Fkͷm|ڋ'4XI"[v;0#u$K ã$ŞZ_M> $,AOL_sv3^mo&i+y^|h["^3yjo4/VY |5Nj0o R  v:h2)HSk IU3umUʓM8::uzdzpx)BMh4k1t 賱_wg} )anR/½&NCh䞺mܔ:T39_>]/Filter[/DCTDecode]/Height 1669/Length 517424/Subtype/Image/Type/XObject/Width 1831>>stream Adobed       '  s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjzm!1AQa"q2#BRbr3$4CS%cs5DT &6E'dtU7()󄔤euFVfvGWgw8HXhx9IYiy*:JZjz ?w\Uؠ`K**|UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثW`vv*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*1Vv WaWbV bd%E(% y} ]J‚0Uē\UHZghW^FJ}Lf<Ą)_ٴU+Wb]v*UثWb]v*UثWb]h4i |\0_$ZVkҮ"a6${W T'9Q %h3in~r :FH!MEr'eoN]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*]v*UثWb\qWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*JU*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]vUij{aVWb ޛw^y_bh]eG;eYm |'W@5BD2$^!UnYiu~l䕂^kNDrZsV] ?,??:.z ْYAu;"RSGg$/"yLm.ʓZ\*HS3U7^.]v*UثWb]v*UثWb]hZ Ox?&+

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Published by Elsevier Ltd. 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(r+V.綍ows*3 46>ClzE/DfQ1947ă?zD&|5=8U̯?% H36נt.^=݆KP} 2y0r!, u:SX=M8t{7mEE AP)M4ܗ8xyMia1@qpKJ}T+;D͸G4cߝ<9 7a:äCCOl!"[xPn $HOcY>&kgr23fI{<=sð'Gz6\ѽBK6`d=XnA72-S6H_s$=Ax*XzRvƇ"+((Dq b ֺ%Y&e|0Q" ipQ(3-7YPFQ=d`fSsw;|MIu}}s)߉N'EE߃J b;JZ܉!MB{g9<򒅑vy)o)c 4{Aڲ:xDrG/Q2Fj m.Q9ؒtOOL44itLK`BQNwOOy'үNͫ测}_yLqf6 E*?fQUHA-Vqpi*1ʜuO۵ Nh` B #G 2Q;"hf.lL-_!tP2 ic\w]}#p ch(ͣFo[9a.bc tr*3~b^/C@4\Õ6_P ]?}zg~m7!΂*+w\gE>2>#@ ,Q2Jv:oG .v }]Kr$k/(_kwRXoaY4g.wxyYڟhV,,s~&q˕.9M+dUi3edC YX#bp8tRx#BqAu[Onپ`-˾<@LB DJ|YNrb@X͗BjcEq9JUyCۯHonn{&`E_."=- vڵYEyÃԲᔞ*38^܂ oߐ"KQ2'K`*jڢ#9j*7dEb-N"l$ ^iqhP%in.MZ)F&J ɰYb,-S$ww]TIl%PO{߂>#mł2Cwۉ6FAS ө<h2g>/b U*85vLbʹfAw_t\. ܑYUsN%8\!@:/bpJ {1Tumn|ӈjM/BX05vU۸ D92EER{-X-|ض( EQ*J7mqK/G$7󆾶nq;9u={n9) (ϣ4b 8B.rRÆl8RWA.NUAKU\]{ȯd=3Huvy!Ig >JvWЄLN^4niac]fyQ_ *߾Y(ɥ4n E:Ƀ`*/iB \L w`V)l1WD2!U kE )S#PY*cf#X6a fQ<.# W"y&O^Q¾ql$Ylf^cz^dOF^̝ȝuw;Ä;CƝ'<=ΈSgĩ'ĩ/g9!2#NLk&&i^eΐ1g0gxsטPVKTn  |f**6q$8f2FDp$UŰW `/xIXH#3x0:y$Np6izULOeɿ(15cDv¼N[1*5J%d)czQp 68RfЉa1{+.:W>Xfdu ~LQj0z<X7uRoNa=>GMaބLa2t #es?(\(44 lU O)XDž%I+ّu\3Rp^.3^ 3Q? БbXu빱jAƈVqV~۵Lpq/j\pT-ml%^}?_`H*ow&= Tmq]"6[(nXu{VÇ"GDnwzuUy+&Yiv.j7qq~>4mZ @apJP;??[{6vj +RqЈ:V̩="9PBfv{JwXwO_$VqG[[)L5یn}J=HE[P_&U7qVۡI6po$FNF,f$.>stream application/pdf doi:10.1016/j.actbio.2019.09.001 A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition Tao Zhang Hui Liu Yating Li Chunyu Li Guoyun Wan Bowei Chen Chunxia Li Yinsong Wang Marine sulfated polysaccharide pH-sensitive nanoparticles Doxorubicin Celecoxib Metastatic breast cancer Acta Biomaterialia, Corrected proof. doi:10.1016/j.actbio.2019.09.001 Acta Materialia Inc. journal Acta Biomaterialia © 2019 Acta Materialia Inc. Published by Elsevier Ltd. 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Published by Elsevier Ltd. All rights reserved. 1742-7061 10.1016/j.actbio.2019.09.001 https://doi.org/10.1016/j.actbio.2019.09.001 P 10.1016/j.actbio.2019.09.001 noindex 6.5 Elsevier 2019-09-14T13:08:42+05:30 2019-09-14T13:07:36+05:30 2019-09-14T13:08:42+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:1d07cb97-65c8-4328-9193-f5f71bac2f1d uuid:d3271a09-51a7-4020-8a69-6416015050ca endstream endobj 36 0 obj <>stream HlRMo / %+jHZ[S=fEmߏ~sf >///qM*e.4N ՖSߔ1-8k6̕ D#/ Q8"w+Ș @ uOs(k+|FRzd2i\s |IjO֣3Yp颲lN6!>Eg ^ri &?蠐72UUlGs͙Uz7!N|>2B~w`:AWzXvXg&Q D^b|m ~2* & IX82]mB\!^67۽J;nہo͡o endstream endobj 37 0 obj <>stream HWYL}7b^EqbwAhS}o/w!<$Yդ a 0TO]hE'{ocN /O]8:{e}'E=E8Ab8p2&$ݹ_ݿcj'/ޣ!y<,C:0LB}guêf_ZogfŹƆȟй[WHV21۷;3x wWF=x0`'4 3 Ow"fh1Oa_F9JƱY[,7p (գʩY6;fk~8 Otb4 >W";׿G[Ă9]L,Oݢɀ р% $GS#X%O,i#IF?YcgO]Sf[/N0bڡY?uEgƩ毰vcv"^7S͛{MoL|v}wBه0Gx >b=6KEp g?չIYpDu?\s\*ڲ }rzSc!ri`# `̐ܫ%1/Pb) C/Ao.KԆ.Xox93HpN`*XY"aƕ:΂ќ+y+ȳ@A*kW<"BU*3j|z̖E8HZZw?1JTuPRS RlA*o*r*ϙqebN95Z 7Q9 U Z,ECڴR$gC%vVeWޘj*ꋦ_y}jt-(<^LHqstgtM!ZAbNᎨ쎤 N0+>2;V{7 ް^>G=2l>V093Gx bʋRH]# ?Yz8fQ A4;usV0:ɥp3ˌxDžyzfiK)ϞYK4dRN ;\rE7Fkͷm|ڋ'4XI"[v;0#u$K ã$ŞZ_M> $,AOL_sv3^mo&i+y^|h["^3yjo4/VY |5Nj0o R  v:h2)HSk IU3umUʓM8::uzdzpx)BMh4k1t 賱_wg} )anR/½&NCh䞺mܔ:T39_>stream application/pdf doi:10.1016/j.actbio.2019.09.001 A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition Tao Zhang Hui Liu Yating Li Chunyu Li Guoyun Wan Bowei Chen Chunxia Li Yinsong Wang Marine sulfated polysaccharide pH-sensitive nanoparticles Doxorubicin Celecoxib Metastatic breast cancer Acta Biomaterialia, Corrected proof. doi:10.1016/j.actbio.2019.09.001 Acta Materialia Inc. journal Acta Biomaterialia © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. 1742-7061 10.1016/j.actbio.2019.09.001 https://doi.org/10.1016/j.actbio.2019.09.001 P 10.1016/j.actbio.2019.09.001 noindex 6.5 Elsevier 2019-09-14T13:08:42+05:30 2019-09-14T13:07:36+05:30 2019-09-14T13:08:42+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:1d07cb97-65c8-4328-9193-f5f71bac2f1d uuid:d3271a09-51a7-4020-8a69-6416015050ca endstream endobj 39 0 obj <>stream HlRMo / %+jHZ[S=fEmߏ~sf >///qM*e.4N ՖSߔ1-8k6̕ D#/ Q8"w+Ș @ uOs(k+|FRzd2i\s |IjO֣3Yp颲lN6!>Eg ^ri &?蠐72UUlGs͙Uz7!N|>2B~w`:AWzXvXg&Q D^b|m ~2* & IX82]mB\!^67۽J;nہo͡o endstream endobj 40 0 obj <>stream HWYL}7b^EqbwAhS}o/w!<$Yդ a 0TO]hE'{ocN /O]8:{e}'E=E8Ab8p2&$ݹ_ݿcj'/ޣ!y<,C:0LB}guêf_ZogfŹƆȟй[WHV21۷;3x wWF=x0`'4 3 Ow"fh1Oa_F9JƱY[,7p (գʩY6;fk~8 Otb4 >W";׿G[Ă9]L,Oݢɀ р% $GS#X%O,i#IF?YcgO]Sf[/N0bڡY?uEgƩ毰vcv"^7S͛{MoL|v}wBه0Gx >b=6KEp g?չIYpDu?\s\*ڲ }rzSc!ri`# `̐ܫ%1/Pb) C/Ao.KԆ.Xox93HpN`*XY"aƕ:΂ќ+y+ȳ@A*kW<"BU*3j|z̖E8HZZw?1JTuPRS RlA*o*r*ϙqebN95Z 7Q9 U Z,ECڴR$gC%vVeWޘj*ꋦ_y}jt-(<^LHqstgtM!ZAbNᎨ쎤 N0+>2;V{7 ް^>G=2l>V093Gx bʋRH]# ?Yz8fQ A4;usV0:ɥp3ˌxDžyzfiK)ϞYK4dRN ;\rE7Fkͷm|ڋ'4XI"[v;0#u$K ã$ŞZ_M> $,AOL_sv3^mo&i+y^|h["^3yjo4/VY |5Nj0o R  v:h2)HSk IU3umUʓM8::uzdzpx)BMh4k1t 賱_wg} )anR/½&NCh䞺mܔ:T39_>]/Filter[/DCTDecode]/Height 1281/Length 373271/Subtype/Image/Type/XObject/Width 1711>>stream Adobed         s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjzm!1AQa"q2#BRbr3$4CS%cs5DT &6E'dtU7()󄔤euFVfvGWgw8HXhx9IYiy*:JZjz ?v*UثWbX&,_.^7fɣ:aT\UFO'D)5 zlqTO,NQaF.@ZWPwQibQZQwϕ^QÕ hzPwPy"L_j⫏7iAUhLU\~nTۋC@t^nMT~YIgkqG,J]`:U}~FU#lUȇoIU_eکuޔA xd~XZ2Gq:T_L,.5!j;Є,H]To?#[Bw˃04l(+Suhm#2BQtF܂xHbi׷݊GULH`6Vjby֝5-IMjo;{bSJ fg^*44j}89O8(cwz֔dBHwbzW1Wyڷ>DA-T٠J6ηZ#K{FJ# j@#NتM/uXy&.J apKefY) PiBz|{8 Y抪T~/y%,2$КS/⯫-{Op2 鱮`ReKQbﳊWmZኽJ:* [rVAIN+$/X[8Ȏ2>/ 1Ve{si:}a*i"X|N6WT&xlP20bwW뿗Ew0,^oRiJlUVv7v>h rX|dEOmDkS%SKx?ߏzoኽHH4Y6y5jK Pvꓺ:>p *~U?4j(## ȓ>׾V ޡ(Cؕ ⩧]wuڵĭ ,}hf;b!ov*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*o=[]iMoknvdִ#p7wյY-._/[ԥ7~*M*Xw$ EJ'#k^kuyu"-[2 wlU/w uuiUST`\U/cg-厠ѐɤ S4>x|WO I{^Ļmpg1PpwPMyj!z֊nMZӿlU8u[2 >/ލ+J_6G>xod(cS8jz(Y#o٨_Ƽ&,V lͧ=EvV`mV5ْY D”D}ITcO$HYmvUoX#e8,BA#ޟbKŕ^q[z I5*9έx6<ʤ%AMRjH,2%GWƘ5o5i$+mipoՄ+*P~ث%{klH&RjԊ,U9-&Ez@y~h۾E)%WP '*/~`yf HP,P֬1VIyTiQOd곺(n5ۍN*ޅO3Y:BKzmJMqTUU{F4 R:E 8Uxu+F$`Xq*Mv5܀1W_j7,˼+zrq؁\Uͮ\V 9;"Ѥ*vvBI+u-:E !5|Uo<[:5kjWiLU^5Z`YcQ3þN*$eFON)CW~XY}5!E(uثo|gayo^qq4WaF_6AlU/~Yy,xQʖh'ۦ*c~a#uvRMS+Ӯ*jj-2J}D,<(6lU3jP7cۼ4T%x UIN銣mOIO&Z5+GR* :Wɗ7w.oQk;f*%7&)W:VMt9= H [O@k=*MelYIrM}xebW"*1 U>UIrZິKU"-%h ;*n/~3Fx֭}TU]" gj0HTCŢ޴sB 4,jrLUN4J7(X'o|x$, x"jw׏cfՊـZ{_<.KgsLyF̍E,{|CsOY%iT%J >„{tKiH8dzhp@hMqV_j*3G"5U*)Cǩ>bOQjRIuhP4J8ިo*^j|3;TZքuN*X*%LK)%[ C^TԮDll yTu!;׵qT[zF,mmn EJG ǐbA{j JڣlU~VAѹ &:bf+lU{/-)ay%C( M jWjU(|k& J2/eN+S^שs%$mXϳUvF[]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb] yM* C!*:*7tڭV =5b٭61V+yO*uзeRNUkK1]_]ܙl( @VUP~N/QVm_aZT;bG]մgh%+~U6_1i7Ǧ YD%*<,qNAv*oKG7 zjCًTኼCͿN HQO{9%%ťzH Su"уVu^Ν?K[\zh)ZqWyJ7\2񋻗 km<\´RĬe>F*-ifJ+@h$Ra~}o3ƄV R1Wy5T:l|=UG>W4}m~PD5䢆9hb=<ťJPZHEf{^w\Bt+/ )?uqO*˿[Sd3DYZx;qW?s+;H~aRMA⯎wBX#2V`WК%QPRK'.1ƪ9u N^%ԑ[ʲ4y?C=1TZ^j;dc?Ăw2(hPoue Z,M$6䬒̀<MASʪz Uu5OYW+莜 I=bҌ6ڂQI7ڔ<_]8Z1!HVFQ^BM*¼e6E0f"E ڄT|UondX,s E)ۯ\UAe%Y%Q:ETxVu|=/'y; 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